Position:  Senior Associate Scientist, Immunology
Location:  Cambridge, MA
Job Id:  005
# of Openings:  1

Senior Associate Scientist, Immunology

Summary:
Solid Biosciences is looking to hire a Senior Associate Scientist, Immunology. We are seeking a highly motivated scientist with knowledge and experience in immunology to help our internal research efforts to understand the immune response to gene therapy. This person will be part of the R&D team with the goal of advancing our understanding of the immune response to introduced AAV vectors, including innate and adaptive immune activation, and how to modulate or suppress these responses in the clinical setting.  Under direction of the Senior Scientist you will carry out preclinical studies to explore immunological aspects of gene therapy that have application to clinical trial design.

Key Duties & Accountabilities:
  • Perform experiments to demonstrate proof of concept and generate mechanistic understanding of immune response to gene therapy using cellular models
  • Establish immunoassays for internal testing of humoral and cellular immune response to AAV  
  • Contribute to in-depth characterization of immune mechanism studies as directed
  • Analyze and communicate data to the project team
  • Performs other related duties and ad hoc projects as required by position
Core Competencies Required:
  • Strong problem solving, data analysis, and interpretation skills
  • Attention to experimental detail
  • Good lab safety and documentation practice
  • Strong communication and collaboration skills
  • Strong motivation and ability to work in a high-paced multidisciplinary environment
Knowledge: Education, Experience, & Skills:
  • BS with 5+ or MS with 2+ in biology and related field with 3+ years’ lab experience in immunology or cell biology
  • Experience in ELISA, ELISpot, and primary cell culture required
  • Experience in cell-based assays
  • Skilled in flow cytometry, immune subset cell, and PBMC isolation, and functional analysis of immune cells preferred
  • Knowledge in AAV vector research a strong plus
Travel Commitment: 
  • Travel may be required up to 10%

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