Position:  Associate/Senior Associate Scientist, Analytical Development
Location:  Cambridge, MA
Job Id:  CO3
# of Openings:  1

Associate/Senior Associate Scientist, Analytical Development


The Associate/Senior Associate Analytical Development will be part of a Biophysical Characterization team whose focus is on characterization of proteins and adeno-associated virus-based products using an array of biophysical, MS-based, and traditional biochemistry tools to support Solid Biosciences’ ongoing program at all phases of development. The Associate/Senior Associate will be responsible for method development and qualification, performing and trouble-shooting experiments, processing and interpreting analytical data, preparing and maintaining test protocols, and data reports. Solid Biosciences’ leading candidate is an adeno-associates virus (AAV) based gene therapy product for the treatment of Duchenne Muscular Dystrophy (DMD). 

Key Duties & Accountabilities:
  • Execute experiments in support of development and qualification of biophysical characterization assays with guidance from senior scientist
  • Plan and execute experimental studies to meet project goals and timelines
  • Provide concise and quantitative analysis of data and interpretation of experimental results
  • Conduct experiments to evaluate physicochemical properties and identify any liabilities that could impact drug substance and drug product development 
  • Write up methods, qualification reports, results and share with team; present data in group and department meetings
  • Maintain records of analytical data, laboratory notebooks, execution of assays, and stability data
  • Performs other related duties and ad hoc projects as required by position
Competencies Required:
  • Excellent communication, technical, and organizational skills required
  • Must be a team player prepared to work in, and embrace a team-based culture
  • Proven troubleshooting, technical writing, problem solving, and investigational skills
Knowledge: Education, Experience, & Skills:
  • Bachelor's degree or equivalent with at least 5 years of relevant experience, or master’s degree with 2+ years’ experience
  • Experience in development and optimization of biophysical/biochemical characterization assays, such as AUC, DLS, TEM, MALS, DSC/DSF, UV-vis, fluorescence spectroscopy, HPLC, LC-MS, SDS-PAGE, CE-SDS, cIEF, etc.
  • Problem solving and troubleshooting skills, along with proficiency in data analysis, and lab documentation
  • Understanding of compliance and cGMP considerations
Travel Commitment:
  • Some travel may be required

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